That's a very good question, and it's a loaded question. The answer is not very easy, but in the case of other illnesses, we do tests, for example, to look at your cholesterol level before you might have a heart attack so that you'll take corrective measures, both in exercise and statins, to prevent a cardiovascular event. If you have some markers that tell you that you are on the road, then you can take corrective measures.
Identifying those markers is not a sentence of any sort; it is just an indicator, like cholesterol. Because you have high cholesterol doesn't guarantee you're going to have a heart attack, but it's a warning sign. If we were able to develop those warning signs, they would be of immense value.
I think it's a continual spectrum. If you look at early indicators that may eventually lead to a condition that's an exacerbation of that biomarker, it will be very useful, because then we can begin to say you will benefit from this type of resiliency-building training, or whatever, and avert an adverse event. I think those biomarkers are very important not just for diagnostics and treatment but also for giving us some guidance as to how we can identify individuals who may need certain types of interventions early on to change the trajectory of how they're going to function later in life.