In terms of harmonization, I would like to make the comment that my sense of working directly in this area is that we will never get to 100% harmonization, because regulators around the world will encounter situations once in a while where they will have legitimate differences of opinion on how data is to be interpreted.
What I would suggest is that we could achieve 90% of the harmonization objectives we have, without even running into those areas of controversy, just by making regulators around the world aware that there are 18 other countries that have office buildings of biologists just like them, and could they please be aware that each other exists. If we could achieve that, we could go so far, without going into those areas of legitimate differences of opinion.