They're listed in the product monograph and they vary. You can go by organ system, and they're listed. They can include severe allergic reactions that can be life-threatening; they can include excessive toxicity, skin reactions, GI reactions—vomiting, and diarrhea. Malarone can cause a chronic cough. Doxycycline is an antibiotic, so it can also cause GI side effects—clostridium difficile, diarrhea.
They both have the possibility of photosensitivity. In many of the areas where malaria is prevalent, there is high sun exposure. These are concerns.
This is why it's important that the physicians involved with prescribing these drugs understand the various side-effect profiles. Many of the severe risks associated with all of them are quite rare, but when they happen, they're quite serious. You have to be aware and have to inform the patient to seek advice from their practitioner; that's why the guidelines are there. The document that CATMAT puts out lists all the considerations of the various drugs that are extracted from the product monograph that Health Canada puts out and from other international information. It really is a consideration at the interface between the physician and the patient, however, as to the best choice and what the strategy is if that choice is not optimal once the patient starts it.