Quite honestly, I don't feel competent to address that question in terms of the amount of research that was put into it by the companies. The information that is submitted to the agency—at least my part of the agency—is specific to environment-related effects.
I think you might want to talk to the companies, but my impression is that there is a large amount of R and D, millions and millions of dollars, going into researching these types of products, and I would assume that due diligence was followed.