Certainly, one of the debated topics within closed containment is that you have tight control over disease, and if you're treating the effluent that leaves that facility, you have the potential for no disease entering the environment, which is really quite good.
In terms of animals that come into the facility, they're generally hoped to be disease-free. So I would imagine closed containment would have a better capacity for regulating release of disease—and, certainly, that is something that a lot of people are excited about with closed containment.