You know that first period of rest that we recommend—that 48 to 72 hours? The studies on the brain during that period, using animal models and fancy imaging, show that there is a metabolic storm in the brain. There is a problem with the flow of ions in and out of the neurons. There's no focal anatomical bleeding or disruption, but there is disruption at the cellular level and there is a metabolic storm. There is high energy consumption at that point.
It's complex, but the understanding of what's happening is evolving rapidly. Hopefully, at some point we might have ways to act at that very acute stage through intervention, but that's not really possible at this point. The only thing we know that's right to do at this point is to respect that initial period where we limit the physical and cognitive demand on the brain during that storm.