I think that's a great question.
Unfortunately, I don't think there's a really simple answer to it, which makes it a challenging area. It's very much a clinical diagnosis based on a trauma, followed by the onset of symptoms and clinical findings. Typically there are no findings on any type of neuroimaging.
In a lot of the research work that we're doing, because there are so many different areas that can be affected from a concussion, we want to look at them all together, so we have people with expertise in multiple different areas all working together. We just finished a five-year cohort study with just over 3,000 youth ice hockey players, where we looked at a bunch of different tests in different areas, looking at cognition, balance, dizziness, neck involvement, some of the mood and other factors, and how those associate with one another. We're actually in the process of analyzing some of that data right now.
We'll build on the SHRED concussions more, where there are also biomarkers, neuroimaging, robotics. There's going to be even greater depth so that we can help better understand what we're actually seeing following concussion to better measure it, which can then help inform that diagnosis piece.
The literature has really evolved over the last few years and is continuing to do so, but because there are so many different components, different areas of the body that can be affected from a concussion, it's certainly an ongoing process that we need to further evaluate.