There are probably two large categories of things that have changed since 1992. One is the body of evidence we looked at and that was available to us to make the assessment about whether or not the products were suitable to be authorized for sale.
The other part of it is the manufacturing process. The way the silicone gel-filled breast implants are made has also changed.
On the information side, on the science side, just in this review when we did the literature studies, since 1950 there have been over 6,000 medical and scientific literature pieces of information that went into this review. When looking at the recent past, there are about 2,500 studies, and a lot of those involve thousands of individuals and have follow-up in the tens of years. So there has been a big body of information.
The things that have come up recently have been primarily around hypersensitivity to cancer involving breasts—whether or not there was an increased risk of cancer. There isn't. The other big category was around autoimmune diseases. That really was the big unknown, looking back to the 1980s and the 1990s. There were a lot of questions about whether or not it caused autoimmune disease. There have been large multiple studies looking at autoimmune diseases, and there hasn't really been a link.
In a nutshell, there has been a significant body of information we've had since that time that went into the review.