Very briefly, the tests that are used to screen donors for the presence of infectious diseases have improved consistently over the years. We started out with tests that unfortunately would miss some infections because they were recent infections, so-called window period infections; the newer tests are better at identifying those types of recent infections. Also, the overall sensitivity of the screening tests that are used to screen blood donors, for instance, and also tissue donors are getting better and better.
We also added recently, in the realm of blood and tissue donation, the nucleic acid test, or PCR, as you referred to it. Those tests will shorten the duration of the window period and therefore decrease the risk.
I strongly disagree with the notion that we can get away from the assessment of high-risk behaviours. We apply those screening tests, which perform extremely well in the area of blood donation, and we still undergo a risk assessment of our blood donors because there are very well documented instances even today...not in Canada, fortunately, but it has been shown in the U.S. that even with the best technology available it can still happen that the blood of a donor will be taken during a period where the test does not perform as expected because it's too early in the infection or what have you.
Tests will never be perfect. They're not perfect now. They never will be. You always need to take into account the risk behaviour.