My answer to your question is that we all think it's very important and that there is definitely a problem. And yes, we're not reporting everything that needs to be reported, and that is also a problem. But it's such a wide spectrum, as indicated by the oncologists in the room. When you're dealing with oncology, it's completely different from dealing with a drug that's being used for blood pressure control, for instance, where your tolerance for adverse events is going to be minimal to nil.
So again it boils down to what is significant. Unfortunately for the individual who's being cared for, “significant” is what is happening to that person.