Adverse drug-related events were estimated to be about the sixth leading cause of mortality. It's vastly underestimated by chart review studies because you're only picking up the ones you recognize and you're only doing it within the hospital. I think that's a big thing. It's like drugs and surgeries. They cure and they kill, so they're potent things.
Teens.... I have two teenagers. We now know that their brains are different. Drugs aren't tested in teens and drugs aren't tested in kids, by and large. So they are social experiments. That's why I am so supportive of progressive licensing and ongoing pharmaco-surveillance for those reasons alone.
I don't think I remember your last question.