A rather mature clinical trial has been under way for many years; over 30 patients with severe MS have been transplanted. They receive an autologous bone marrow transplant of purified hematopoietic blood stem cells. Essentially, this reboots the immune system. You have to receive all your vaccinations, otherwise you'll get all your childhood infections all over again, and then the rebooted immune system forgets it's attacking the nervous system. So essentially you no longer have MS. Those patients do very well.
The younger you are, the better the outcome, but we know of particular patients.... Jennifer Molson is one who was in a bed. She had to be fed. She had to be taken care of by personal caregivers. She was in a rehab facility. She's now skiing. She's working. She's living with her husband. She got her driver's licence. It's phenomenal.
That work is being performed by Harry Atkins and colleagues at the Ottawa Hospital. It's not published yet, but I'm sure it should be coming out in a high-profile journal. It changes the practice of care.