I would add that it underscores the need for our evaluators to stay up to speed as well on developments. One of the things we try to do is ensure they have access to experts in the various fields. We just won't be able to, nor should we, hire every leading-edge expert for doing the reviews. We want them out there treating patients.
We have a series of advisory committees and on those committees we have experts from the various areas, so that we can get access to the expertise when we need it for review.