Thank you. I'll answer very quickly so we can hear about dealing with innovation successfully.
The short story is, the stuff you need to go through regulation is different from the stuff that people who pay care about. So if you're doing regulation, you could do placebos, you could have super-healthy young patients. When you go to the real world, it's possible doctors aren't treating people with placebos. It's possible some people who get sick aren't young and healthy. It's also possible you'd want to study people for longer than, say, six weeks. The evidence we need for the regulation part is different from the evidence we need for the payer part. If you can produce pressure to get it paid for by doing just the regulation, why would you collect the other stuff for the payers?