Much less so than what you might think, for two reasons. One is, in this age of Internet and PubMed searches, one really has at one's disposal a vast body of information from all around the world. At the research level, I think you really are aware of what's going on.
When you get to commercialization, the first thing our commercialization office does, if we bring a disclosure to them, is try to find out if there is competition. Is there space in the market? Is somebody else doing that? Although you don't know everything in the commercial world because some of it is not public, I don't think reinventing the wheel is one of our barriers here, or that we're wasting a lot of money reinventing the wheel.