In regard to why there's been a change in recent years, again, I think it goes back to availability and to a changing culture in medicine. It used to be that opiates were reserved for end of life care, acute management of injury or post-operative care. However, in that timeframe, from the late 1970s through the 1990s, there was a shift towards the use of opiates for non-cancer related pain, for chronic non-cancer pain. It was not just a shift to the use of them, but a shift in the thinking that we should give maximal doses to relieve people's pain completely, without the research basis for the effectiveness of that model. That's the spiral you're talking about.
We're now in the phase where we've seen that the pendulum has swung too far and we're trying to bring it back. It's going to be a process. It's not just the physicians who have their hands in this pot now. As you said, there are the manufacturers, the dispensers, those who would profit from it illegally, and there are the patients themselves and their expectations. All of this needs to be brought back to a more moderate approach and to one that's based upon evidence showing that, in fact, giving people these drugs does make their life and their situation better. We don't have that evidence right now.