Thank you very much.
It's certainly a pleasure to be here in front of this committee. Thank you very much for the opportunity.
I'll open by saying it's a privilege to be here because of a number of things. Coming up the street in a taxi, as an ex-serviceman and a father of a reservist, I had the opportunity to see in front of me that memorial. It was a very emotional experience. In addition, it's the week coming up to Remembrance Day. In fact, it reminds everybody that today in 1917 our Canadian soldiers took Passchendaele.
With that, I'll try to emphasize the same passion in my knowledge and support for e-cigarettes, and be happy to answer your questions.
I will tell you a little bit about myself. I'm not new to safety or innovation. I established a community cardiac surgery-based practice in Canada. We're now one of the three largest beating-heart surgery centres in North America, meaning we don't stop the heart-lung machine. We did that specifically to improve patient care, and we are lead benchmarks for surgery. I was chief of staff at our hospital, so having to look out for people who could not look out for themselves has been a great passion of mine.
After six months of research, I'll declare that I did find an e-cigarette retailer, but I also advise people to have heart surgery and am renumerated for it. In fact, every physician is remunerated for recommending their treatments, and I would not at all be involved in or stand in front of you to create any kind of bias. I would be happy to address any questions you may have in that regard.
In fact, this is the enemy. The smoking I see every day clogs arteries. That's what I make my living out of. It causes lung cancer.
This slide shows an individual in her last stages of palliative care, and we need to stop this. Of what you see in front of you, 85% to 90% can be prevented.
This slide shows the leading causes of lung cancer: smoking; radon gas we've been able to get rid of; asbestos we regulate and get rid of; air pollution. Air pollution is out there. It's not safe to breathe in our cities.
I want to address clearly some fundamentals of the safety of e-cigarettes for users. No adverse health outcomes were seen when primates were exposed to continuous high concentrations of polyglycol vapour. The primates and mice were put in a box and were given high concentrations to breathe for 12 to 18 months. Histological samples of the lungs were taken and we could find no chronic effects or changes in those lungs in the deep alveolar tissue.
When smokers are able to go off tobacco smoke, they experience immediate beneficial effects.
On pulmonary inflammatory disease, I tell my smoking patients they have to stop smoking two weeks before surgery. The risk of infections is far less because the immune system of the lung improves as soon as we get people off cigarettes, aside from it simply being a long-term cancer-causing agent.
I'm going to use some terms. I want to talk about cytotoxicity, and that's the potential to cause harm or cancer.
Essentially you take the liquids, you take your chemical, you put them on cell cultures and you study them under the microscope to see if there's any change in their DNA. Does it damage the cells in any way? What we see is that when you actually apply the polyglycol vapour, or e-liquid vapour, you see no cytotoxic changes to those cells. These can be fetal cells. They can be stem cells. So you can place it directly on these cell cultures without any effect.
If you do the same thing with extracts from tobacco, even down to a 5% solution of tobacco extract, it causes mutations in the genes of those cells.
In terms of the safety for bystanders, remember that a regular cigarette burns at the end. If you're sitting there and you're a bystander, you're getting the direct effect of that. Any vapour that's inhaled from an electronic vaporizer is first absorbed into the user. What comes out is what's left after absorption, and it's typically just a polyglycol vapour. There are very small amounts of nicotine in it. There have been studies that have shown bystanders will be exposed to nicotine. If you actually take a look at the way those studies were done, it was vaporized into a box. Essentially, to put it into context, you would have to lick the entire inside of the box to get any meaningful amount of nicotine, if you're a bystander.
If you take a look at heavy metals that can be possibly produced in it, they are detectable but are less than 1% of threshold values that you would consider safe if you were to walk into any factory or workplace today. And that's for the user. The bystanders are going to get even less.
I only put up this slide to simply show you there is no mystery around what's in vapour.
Chemical chromatography, liquid chromatography...we can identify all the chemicals that are in there. It's not a mystery. We know that every one of those chemicals, if they exist or are detectable at all, exist at threshold levels that are well below occupational health and safety standards, even if you provide a factor of 10 as a safety margin. This slide shows the same.
This slide compares Nicorette inhaler mist compared to that found in electronic cigarettes. We can see that if you were worried about formaldehyde—a lot was made about formaldehyde—the original FDA trial said there's formaldehyde in it....
There was a question earlier on in the session about the temperature of vaporizers. E-cigarettes vaporize at about 60 degrees. If you vaporize polyglycol at 280°C, in fact you burn it, you will create trace amounts of formaldehyde. An electronic device is incapable of creating that temperature. What we see is a profile of toxicity that's similar to something that's already approved today, that being the nicotine mist vaporiser.
Our youth are very important. I have kids. I don't want them to be exposed to anything toxic. I don't want it in our schools either. But what's the reality? If you take a look, unfortunately, kids somehow get cigarettes. They're banned and they're not supposed to get them, but still they do. We see, shockingly enough, as I was telling my son, that one in 100 of kids in grades 6 to 9 smokes cigarettes. Where do they get them from? We know that by the time they're teenagers, we have rates as high as 14% of kids who are not supposed to have tobacco in their hands or have it available, but somehow they get it. So for me the issue is, why are 14% of our kids smoking?
If we take a look at the United States, the current user prevalence in U.S. adolescents, have a look here, if you take a look at e-cigarettes only, up to about 25% is a very small part. Most are in fact dual users of the ones who use electronic cigarettes.
This study was performed in the United States and it shows a drop in smoking rates. If you take the top and you say, well, the use of electronic cigarettes has doubled. We see young people walking around with electronic cigarettes, it's an epidemic. But, in fact, if you take a look at it, very few of them are using e-cigarettes only. Almost all of them, 99% of them, are previous smokers. When I look at a slide like this, yes, I can worry about the 0.6%, or I can really be dreadfully afraid of that 11.8%, because if you started smoking as an adolescent, your profile of getting emphysema, lung cancer, and heart disease, is huge over your lifetime.
With regard to nicotine safety, nicotine is an alkaloid. It's found in plants. It's made in their roots. You can find it in eggplants, tomatoes, black peppers; it's in the highest concentration in tobacco. Why does tobacco actually have nicotine? It's an insecticide. It protects the tobacco plant from being eaten by insects, so that's why in days gone by high doses of nicotine were used as an insecticide. In fact, a question was raised about the toxicity of nicotine. In industrial-available strength, nicotine is toxic. It will cause seizures and vomiting, and it can be lethal. Outside of an industrial factory, those concentrations of nicotine are not available.
It does not cause cancer. It can be addictive, but there are no serious health care outcomes related to nicotine alone in the concentrations that are available today. Much is made about a child eating or drinking nicotine. Most likely if that happens, they will vomit. It is not fatal. They will vomit even if they like the flavour. They will take it, it will irritate, and they will vomit.
With regard to nicotine safety compared to analgesics, liquids, cosmetics, vitamins, there are very few—618—annualized calls to poison control centres, compared to over 200,000 calls for something like cleaning liquids and cosmetics.
On nicotine as a gateway to other drugs, the Polish study was mentioned. However, in a huge U.K. study as well, and if you take a look in Germany, the number of electronic cigarette users as a percentage is always around 0.1% in youth. There's no molecular mechanism or clinical mechanism, aside from a very small Polish study, that would indicate that people will start with electronic cigarettes and move on to something else.
I want to emphasize that.
Smoking rates have gone down very consistently since marketing has been started to counteract tobacco advertising. But we've plateaued. In fact, now we're in the endgame for a tobacco-free society. That's where I certainly echo the sentiment of physician members and committee members. I would like to see a tobacco-free society. How can we let this occur? We've got the low-hanging fruit. The people we could get off tobacco, we've gotten off tobacco by every means. What's going to get us down to 0%?
Much is made about smoking cessation. The ITC studies say that people who incorporate electronic cigarettes in their regime cut back their exposure to cigarette smoking from about 20 to about 16. It's helpful in reducing emphysema, cancer, heart cessation rates because it's a dose-dependent phenomenon. The more tobacco you take, the worse it is. So you don't have to go from up here to zero; coming down on the scale is beneficial. We can see here, lung cancer in men, cigarette consumption in men. The more you smoke, the worse it is. You move people down that scale, you lower their risk.
Once again, I want to emphasize a lot: tobacco harm reduction. Cessation is an all-or-nothing phenomenon. Tobacco harm is proportional.
This is a great slide. I draw your attention to it. The fact is, if you can reduce people's cigarette consumption, you reduce their relative risk almost exponentially. Take a look at people taking a pack a day in that pink bar. You get them down to 10 cigarettes a day and the trials, both Burstyn and Polosa, have shown that you can reduce cigarette consumption by about 50%. So you're taking people down into that very low column. Are they at a higher risk than zero? Unfortunately they still are. But you've reduced their risk twofold.
In smoking cessation therapy, we can take a look at e-cigarettes and they have gone up. There's a reason they've gone up. Despite all the thinking that experts have, we have failed smokers in being able to get them off cigarettes. We can applaud ourselves about our medical therapy, about our pharmacology, about our drugs, but one in five Canadians still continues to smoke.
I would congratulate you on many respects but one is that you have undertaken more due diligence at this committee than has been done by the FDA, by the World Health Organization, and by the CDC. None of those august organizations that many of the population depends on for clear and accurate information undertook this level of diligence. When you read statements from the World Health Organization, the FDA, and the CDC, those decisions were made behind closed doors. Their review process was not transparent at all. I don't really understand why they say what they did. On the re-normalization of smoking, the gateway phenomenon was attributed to Mark Frieden. He is the director of the FDA. I don't know why he believed that. I have no idea why he made those statements but he did. Because he's director of the FDA, everybody puts credence on that.
I'd like to conclude. I know I'm running short on time. I don't want to take any time from my august member here. So, available cytotoxic and chemical analysis shows e-cigarettes have a risk profile that is orders of magnitude less than traditional combustible. Nicotine does not cause cancer. Tobacco kills people. There's no evidence on a molecular level from the New England Journal of Medicine or epidemiological studies aside from only one that e-cigarettes are a gateway to progressive use of worse substances. Tobacco use in our youth remains the concern. In fact, the presence of e-cigarettes could be argued to be reducing the use of combustible products. Flavoured cigarettes, although they have been available in Europe for a decade...still only .1% of all e-cigarette users are youth.
Research indicates that second-hand vaping is not a concern.
My suggestions are—I'll run through these; I believe we can all read—that a new category of tobacco harm reduction tools should be created because we cannot predict the future. Let's create a regulatory and structural framework where we can continue to evaluate new products and tools as they come along.
We certainly need to have manufacturing standards for hardware, the battery composition and duration, and you need to establish standards for your liquids. People cannot be making this stuff up in their garage. That's not what we want. We need manufacturing facility requirements. We need labelling. I believe that nicotine can potentially be toxic in high concentrations. We need a lot of tracking mechanisms to know about product recalls and ingredient quality. Certainly, they need to be bottled in a way that it's as difficult as possible for children to get at it. Restricting the sales and products, I think we've been over that.
There is some sort of statutory warning perhaps for women who may be pregnant because there might be some effect on very early fetal cell tissues. In principle, I think there should be some advantage to using electronic cigarettes financially and socially over using a traditional cigarette. I'm not going to suggest exactly how that is. Any type of lifestyle advertising should be banned. I believe that it should be promoted as a tobacco harm reduction strategy. Much has been made on the sale of youth flavours. I'll leave that and answer that during the time for questions, but it should be based on consumer demand.
Increase taxation of tobacco products if we think we're going to lose taxes by the use of tobacco products. Make it more expensive to use whatever tobacco products there are out there, but give some incremental advantage. I believe that the same health care organizations that are saying that there's insufficient evidence should be charged with funding unbiased brand-neutral trials. A standing committee of tobacco harm reduction should be part of the health protection board, that I have occasion to deal with and have helped me to treat a great many patients over the years.
Thank you very much for your attention.