I'll start and I'm sure others will contribute to this. I think what you've put your finger on is really at the core of the problem.
We wouldn't prescribe these drugs if they weren't powerful, so these are powerful agents for good, but they are also powerful agents of potential harm. The problem is we can't look into the future and see with any degree of certainty whether any given prescription is going to cause more good than harm.
We can certainly, based on risk factors, based on genetics, based on past experience with this particular patient, try to predict that, but in fact the power of these medications for both good and harm is at the core of the issue that we're talking about today.
What we're emphasizing these days as a starting point for treatment, and I'm sure a few of our witnesses here today will agree with me, is non-drug treatments around all the conditions that people are up against. People working on diet and lifestyle questions, working on physiotherapy or rehabilitation measures that can help deal with pain, as the speaker before said, addressing some of the most important non-medical determinants of whether someone gets sick or gets better quickly is equally as important as writing the right prescription.