Michael, I'll tackle it first.
Basically, I think clinically introduced DNA sequencing will identify these individuals before they manifest their symptoms. That's the short answer. We have newborn screening in our institution where we look at 150,000 babies a year. For Ontario we study 40 diseases. With new exome sequencing, in the brave new world we'll be able do for it hundreds and thousands of disorders, to identify those pre-symptomatically.