I wish I could. Unfortunately, I don't have the in-depth knowledge about what goes into our clinical trials.
First of all, let me just say I hope that your children are doing well living with the rare disease. I hope that innovations have been able to give them a quality of life they deserve. A lot of that is due to the work done by the innovative pharmaceutical industry, so people like you and Ian and his daughter actually have the opportunity to live fruitful lives here in Canada.
In terms of research and development costs, they are significant and that doesn't account also for so many failed molecules that never actually make it to market.