Good afternoon. Thank you, Mr. Chair.
Thank you very much to the committee for giving us the opportunity to address the committee this afternoon.
My name is Volker Gerdts. I'm the CEO and director of VIDO-InterVac. I'm joined by Dr. Paul Hodgson, who is our director of business development. Both of us have been with the organization for more than 20 years, and personally, I'm still a researcher. I still run a lab and I'm also a professor here in Saskatoon at the University of Saskatchewan, at the local veterinary college.
This afternoon we were invited to talk to you about the ongoing efforts here in Saskatoon at the University of Saskatchewan, so I thought I would start by quickly giving you an introduction to VIDO-InterVac, which stands for the Vaccine and Infectious Disease Organization - International Vaccine Centre, a very long name. It's one of Canada's largest research organizations and is focused on infectious disease research and vaccine development.
We are truly a national facility, collaborating with researchers all across the country. Our InterVac facility, our high-containment lab, which I'll speak about in a second, is really designed to facilitate research in Canada by bringing in collaborators from all across the country to use our facilities and take advantage of the unique infrastructure that we have here.
VIDO-InterVac is a global leader in infectious disease research. We have more than 45 years of experience working in both the animal and human health sectors. We have developed 10 vaccines over the years, six of which were world firsts, so that really speaks to the type of research that's going on here. We have quite a bit of experience working with coronaviruses as we develop vaccines in animals, as well as currently also working on MERS, another coronavirus.
I'll give you an example. Just a few years ago, Canada was facing a coronavirus in pigs that was very similar to what we're seeing now. We responded to it as quickly as we're doing now. We made a vaccine in 18 months, and the vaccine for pigs is being licensed now to commercial producers.
Our research here at VIDO-InterVac is really addressing the threat of emerging diseases. We're one of the few labs in Canada right now that is equipped and has the infrastructure available to work on these emerging diseases, including both emerging human diseases such as the Zika virus, the new COVID-19, MERS or others, and animal health threats such as African swine fever, a very important disease that is currently threatening the Canadian pork industry. That is also being researched here at VIDO-InterVac.
To speak directly about our activities on COVID-19, we started our work immediately when the World Health Organization recognized on January 9, I think it was, that there was a new virus in China, a potential new problem. The same afternoon, we decided that we would start working on a vaccine for it. As soon as the sequence for the virus became available, we designed our vaccine and immediately started to work on it.
I also reached out to Dr. Matt Gilmour, who is the director general of the National Microbiology Lab in Winnipeg, to ask whether there was anything that we needed to do together, anything that VIDO could help him with. I'm proud to say that in collaboration with our colleagues at Sunnybrook and in Winnipeg, VIDO-InterVac was the first lab in the country to isolate the virus from a patient sample. We were the first lab in Canada to have an animal model developed, using ferrets for this. Now we have a second model in hamsters, and we're even working on a third model in cats. We are currently the first lab in Canada to have its own vaccine, which we started to develop right in January, and it is already in animal testing.
We call that the proof of concept stage. We already have animals vaccinated with our vaccine. Next week, these animals will be challenged with the virus and we will see whether the vaccine actually works.
All of that work is happening in our InterVac facility, the International Vaccine Centre. It's one of Canada's and the world's largest high-containment facilities, which speaks to the foresight that the government had several years ago in building a facility that allows us to address emerging diseases when they arise. We can house in there hundreds, if not thousands, of animals right now for our COVID-19 research, and we can host researchers from all around the world to perform this research. For example, Dr. Alyson Kelvin and her group from Dalhousie University are currently running a ferret trial here at VIDO-InterVac. There is a lot of interaction and research going on in collaboration with others right now.
In fact, we now have more than 100 requests from partners all around the world, including big organizations like the Bill & Melinda Gates Foundation, as well as large industry and academic collaborators that want to use these animal models to look at antivirals and drugs and to even test other vaccines. In response, we have ramped up our capacity, and essentially our whole organization is now focused on COVID-19 research. We're using all the infrastructure that we have available right now to run as many studies as we can in parallel.
That initiative was recognized by the government, and we received generous support to do some of this work, which I'd like to acknowledge. You all may have seen the Prime Minister speaking directly about the $23 million for VIDO-InterVac to accelerate our vaccine development. That money will help us to take our vaccine directly into clinical trials.
The prototype of the vaccine has been manufactured already. Over the summer we will do the necessary safety testing—it is very important that we not take any shortcuts there—and we're looking forward to starting our clinical trials in the fall.
There was also an announcement of $12 million for our manufacturing facility. We have been working on this for a few years. Establishing a manufacturing facility right here at VIDO-InterVac in Saskatoon would allow us to essentially take prototype vaccines like the ones we have right now into clinical development to fast-track the process and make it more effective. With the $12 million, we will be able to do this. We're establishing a GMP manufacturing facility right here in Saskatoon, and that will enable us to not only develop or manufacture prototype vaccines for clinical testing, but also, in the long term, manufacture vaccines like the COVID-19 vaccine.
There was also funding from CFI to operate our InterVac facility, and we gratefully acknowledge that it was great support for us. It helps us to operate the facility and has helped us ramp up our research capacity for this work.
It is also important to mention that the Province of Saskatchewan, through Innovation Saskatchewan, provided $4.2 million to help us in our COVID-19 research.
Where are we right now? We're doing a lot of studies currently that address antivirals, as you heard earlier. Other producers and other manufacturers in the world have a lot of promising candidates. There are also some new compounds that hold great promise. We're testing them in our animal models and are offering that testing service to everybody around the world, including the World Health Organization. We're participating in three expert groups with the World Health Organization, and we were part of the expert meeting in Geneva that was organized in February. A lot of our contract requests come from international partners that are asking us to help with their antivirals and therapeutics.
On our own vaccine, as I mentioned, the safety testing will continue over the summer, and we will be able to do the clinical testing early in the fall. One of the highest priorities for us—and that's why I'm saying it again—is to make sure that this vaccine will be available to Canadians. It's a Canadian effort. We have partners in Canada involved in Montreal and we have collaborators from all across the country. The clinical testing will be done at Dalhousie. This is truly a Canadian effort, and the goal is to make sure that this vaccine will be available to Canadians all across the country.
We were asked to quickly address what vaccines are and the differences in these different vaccines.
The technology we are using is called a subunit vaccine, so only a piece of the virus is being used. We're using one of the structures, one of the proteins the virus has.
Other vaccines that are currently being developed globally use the whole virus. That's what we call an inactivated virus. We're just using the viral genome, which in this case will be RNA, although we can also have DNA vaccines.
Last, you may have heard about vectored vaccines. With these, we're using another virus, a viral vector, to deliver just a part of the genome of the virus as a vaccine vector.
Finally, I want to mention our efforts in helping our local communities.
Two weeks ago, we reached an agreement with the Saskatchewan Health Authority. We are using our facility to sterilize and decontaminate N95 masks and other protective equipment. We had this process approved by Health Canada. These masks are now being collected in the hospitals and are being shipped here to VIDO-InterVac, where we now essentially decontaminate them with vaporized hydrogen peroxide, or VHP, which we use here routinely for our processes. We can now decontaminate thousands of masks every week and ship them back to the hospitals to be reused.
My take-home message or summary is that at VIDO-InterVac, we're proud to be part of the national emergency response. We're proud to be part of Canada's response to this COVID-19 outbreak. As an organization, we are very uniquely positioned to rapidly respond to these emerging diseases. We very much acknowledge and are thankful for the support from the federal government as well as the provincial government. While this is helping us a lot in our efforts, and there's a lot of money available now, I think the real message is that we will continue to see these emerging disease outbreaks in the future, so it's very, very important for a country like ours to provide long-term support to organizations like ours, which are uniquely positioned to quickly address these challenges when they come.
Thank you very much.