Certainly cystic fibrosis has been front and centre in the effort to try to get access to Trikafta, which has been considered the A+ therapy for patients with cystic fibrosis. Unfortunately, because of the PMPRB, the company has been very clear that it cannot bring it into Canada at this time. The impact on our pricing would be such that it would not only not be affordable for us, but it could also damage us further.
I think that has created a huge problem. They're not the only patient-to-organization, not the only disease, that's impacted in that way, but they've definitely been able to raise public awareness, and the fact that a young woman died in Nova Scotia.... Again, we have no clear evidence that she would have been saved by Trikafta, but she was definitely of the patient profile that would have benefited from it.
The other thing that happened, of course, is we didn't get the clinical trials in Canada. Again, early on there was the recognition that this was not going to be a country where we were going to bring this in early. Unfortunately, because of the way the system is set up, if you've got the patient on the clinical trial, you can't just drop them. I think companies are unwilling to risk the fact that they may have to keep a patient forever, or for many years, and this is reverberating through many of our rare diseases, including cystic fibrosis.