Good afternoon, members of the committee and fellow witnesses.
First of all, let me thank you for the opportunity to appear before you today to speak as the president of the Canadian Society for Virology. I am very proud to lead this young not-for-profit society that I co-founded in 2016 with Dr. Craig McCormick, a professor at Dalhousie University.
CSV was originally founded to help Canadian virologists who were spread across the country, including world-renowned experts in basic, clinical and epidemiological research, to come together to exchange ideas and discover new opportunities for collaboration to meet the challenge of existing and emerging viral infections and realize their potential to lead in this research area. CSV now counts 220 members, who study viruses that infect human, animals, plants and bacteria. CSV members represent universities, hospitals and research institutes across the country. The society provides unique opportunities to bring the community together and foster exchanges, thus promoting collaborations to accelerate discoveries and the translation of research findings into positive health outcomes for Canadians. Canadian virologists have made important contributions to the fundamental understanding of many viruses, which has led to the development of new strategies for monitoring, preventing and solving global health challenges related to viral infections, such as, for example, the Ebola virus vaccine and anti-HIV drugs.
As you can imagine, our community quickly plunged into the heart of the current global pandemic and is at the forefront of research to contribute to the understanding of SARS-CoV-2, the virus responsible for COVID-19, from a biological and epidemiological point of view and its diagnosis and treatment through antivirals or vaccines.
The outbreak of SARS-CoV-2 was under the radar of members of CSV, including members of the executive, as soon as it appeared in China in December 2019. The immediate action of CSV was to contribute to the organization of support for health care workers, medical microbiologists and virologists in China to help contain the outbreak, treat patients and protect front-line workers who were facing shortages of protection equipment and supplies.
With the leadership of CSV executive members, together with Dalhousie University and members of the Canadian medical community, about $48,000 was raised through donations and used to purchase and ship Tyvek suits to hospitals in Wuhan.
Members of our community, including clinicians and microbiologists, were part of the team managing the first COVID-19 case in Toronto. Through collaboration with other CSV members, they quickly achieved laboratory culture of the virus. Other collaborative teams took alternative routes to culture the virus and very quickly test animal models, which are key to antivirals and vaccine development. These tools are now spread through our community, which is responding in an exceptional way by quickly redirecting the research to respond to the urgent need to better understand SARS-CoV-2, improve diagnosis, identify therapeutic strategies and develop vaccines.
The community effort is immense, and we want to acknowledge that this was only made possible thanks to the very quick response of the federal government and agencies. The major investment in COVID-19 research, made through the CIHR, NSERC, SSHRC, CRCC, new frontiers in research fund, the International Development Research Centre and Genome Canada, has strongly supported the effort made by our community. It would not have been possible without this investment.
This must, of course, be underlined, but it should not make us forget the reasons that have contributed to the lack of preparedness in facing the current pandemic. Indeed, the lack of funding for investigator-initiated fundamental research over the years has strongly limited the diversity of research that could have given us an advantage over the virus. In fact, over the past decade, scientists have raised awareness against the class of viruses to which SARS-CoV-2 belongs. It was clearly established that the most probable naturally occurring threat that humans face is from a respiratory-borne RNA virus.
This class of microbes should have been a preparedness priority. I personally raised awareness about it to the CIHR's infection and immunity institute advisory board last year. The SARS epidemic in 2003, which had already affected Canada, should also have sent the signal for the necessity of preparedness. Scientists are in the best position to keep watch on the emerging fields. In order for them to translate their observations into knowledge and tools to face emerging infectious diseases, they need continuous and sustained funding for investigator-initiated research.
Major investments were made at the time of the SARS epidemic, but once it ended research funding in this area was limited, and advances that had been made were stopped. If global research had continued, we could have had antivirals and/or hints for quick development of vaccine candidates against SARS-CoV-2, a closely related virus.
Accumulation of knowledge, including biology, interaction with the host, epidemiology and ecology, of diverse viruses would give us an advantage in the anticipated fight against emerging pathogens. As such, let’s not repeat history and cut funding when this pandemic comes to an end. Let’s also not make the mistake of focusing only on coronaviruses, but rather on a wide variety of viruses, as we do not know what the next threat will be.
Importantly, SARS-CoV-2, like SARS, is a zoonotic virus, meaning it spread to humans from an animal. This pandemic is showcasing how viruses jumping from other species can be a threat to humans, and further underscores the necessity of funding research on viruses of diverse origins, not only human.
Expertise in the manipulation and study of human-threatening viruses, and the development of antivirals and vaccines, requires years of training. CSV members are currently training the next generation of virologists, and CSV is dedicated to providing support through career workshops and opportunities to network during sponsored symposia, awards and lab exchange programs.
While CSV members are now focusing on COVID-19-related research, their research program on other viruses is on pause. It is essential to expand research capacity in order to ensure a broader scope of research on a variety of human and animal viruses.
Importantly, to fight viruses, virologists cannot work in silos. They need training in, or collaboration with, researchers with expertise in immunology, vaccine and drug development, epidemiology and ecology. Canada should support careers and build capacity in various areas of virus-related research such as fundamental research, epidemiology and drug and vaccine development by raising the profile of those career opportunities and creating supportive environments for training.
The study and development of therapeutics and vaccines against emerging pathogens causing threats to humans, such as SARS-CoV-2, requires experiments that must be done in high-level containment level 3 facilities. It is key that this infrastructure across Canada meets all the government laboratory biosafety guidelines at all times. This is essential for researchers to perform the required experimental work to build knowledge on viruses and respond quickly to a situation of threat.
This was not the case in this current time, as several facilities were not certified and could not have been updated over time because of lack of funding. It is important that the federal government commit to secure funding for building capacity and maintenance of containment level 3 laboratories and animal facilities, which are essential for a response to any emerging pathogen. The development of these laboratories should not only be in the form of infrastructure funding, but also in the form of operating funds.
In closing, I want to leave you with the following take-home message. The spillovers of emerging infectious diseases are continuing to increase and the current pandemic will, unfortunately, certainly not be the last. Increased preparedness through funding investigator-initiated research and infrastructure will cost far less than the public health and economic toll of another virus that we may have been able to identify and contain earlier.
It is essential for the CSV community that the required increase in basic virus research is not done at the expense of funding for other fields, threats or diseases. Virus-related research is part of an ecosystem that overall urgently needs more investment for fundamental, investigator-initiated research.
Lastly, I'd like to stress the fact that CSV members mobilized in an exceptional way in response to the current COVID-19 pandemic. They were able to quickly redirect their research, something that would not have been possible without the federal government's major investment in COVID-19 research, made through the CIHR, the Natural Sciences and Engineering Research Council of Canada, or NSERC, the Social Sciences and Humanities Research Council, or SSHRC, the Canada Research Coordinating Committee, or CRCC, through the new frontiers in research fund, the International Development Research Centre, or IDRC, and Genome Canada.
Unfortunately, we are experiencing the insidious effects of years of underfunding for non-targeted basic research. Adequate investment would have meant that we were better prepared to deal with emerging infectious diseases. Scientists are in the best position to keep watch on these emerging fields, but they need the resources to translate their observations into cutting-edge research.
Their message is this: the repercussions of emerging infectious diseases continue to increase and the current pandemic will unfortunately not be the last. Increased preparedness through funding of research and infrastructure will decrease the public health and economic toll of another virus that we may have been able to identify and contain earlier.
Lastly, it is essential that the required increase in basic virus research is not done at the expense of funding for other fields, threats or diseases. Virus-related research is part of an ecosystem that overall urgently needs more investment for fundamental, investigator-initiated research.
Thank you, and I would be happy to answer your questions.