Yes, I can attempt that.
NACI has advised us that, based on what we know about the immune system, intervals that are longer can provide the immune system more time to generate a robust immune response. We have seen in some of the clinical trials, such as those for AstraZeneca, that a longer interval resulted in more protection and a better immune response. There have also now been some studies published showing similarly for the Pfizer vaccine that a longer interval can provide a stronger immune response.
These are all things that the committee continues to weigh out, as they look at the interval strategy. As Dr. Tam said, jurisdictions are now looking at whether they can revise their strategies as supply shifts. NACI has always said that an interval of up to 16 weeks could be used, based on their deep understanding of the immune system, immune responses and what we've seen historically from other vaccines—that more time can allow the immune system more time to generate a better response.
Thank you.