I'll start, but it may be Dr. Lucas who's in a better position to answer this.
All I know is that the clinical trials and the recruitment of participants have included both males and females in a good proportion, but the trials are done in tens of thousands and can't scope in every single population group. It's not just sex differences. There are other differences.
As for pregnant women, we need more studies there in particular. We're following pregnant women through registries, but it is a very important point. In fact, through preclinical trials all the way to clinical trials, you need to take a sex-based approach, including in animal studies even, and I think the regulators have some requirements on this front.