Thank you very much to all the panellists.
I want to acknowledge the courage of my fellow panellists for speaking up. I don't think we hear enough in general from people with lived experience, and hearing testimony from panel members themselves is extremely powerful.
Dr. Yaffe, I'll go to you, but I'd appreciate brief answers, with full respect. I'd love to spend hours on this, but I only have three minutes. I'm going to share some time with my colleague Dr. Powlowski.
Regarding randomized trials versus observational trials, what I'm taking away is that we can no longer do the randomized trials that were done in the fifties and sixties because it would be unfeasible to do a control and test group, let alone with the evolving technology. In other words, we can't really replicate previous gold-standard trials.
Do you favour the U.S. approach, which is to understand the basic concepts and then move on and use only modern trials from 2016 onward, even though most of them are observational? Could you quickly comment on the merit of that approach?