It's a very complex situation, and it really depends on the degree of rurality and remoteness we're talking about.
There are a large number of “fly-in only” communities in my province, and often, almost exclusively, they are communities that don't have pharmacies and don't have the ability to dispense medications within the communities. That is a major barrier to the use of medications that have to be witnessed and dispensed by either a pharmacist or a health care provider.
The advent of long-acting injectable buprenorphine has enhanced the ability to provide treatment for opioid use disorder in those communities, because it doesn't require daily use of medication. That is another area where the availability of long-acting injectable naltrexone, which I mentioned, would be useful in terms of providing another treatment option for people who either don't want to or can't go to the pharmacy regularly for medication options.