The challenge with the lack of pediatric formulations for children results from using adult formulations off-label. What this tends to mean for children is compounding of drugs. In some forms it's a pharmacist, either in a hospital setting or in a community pharmacy setting, crushing a tablet. It could sometimes be parents crushing tablets and mixing them with apple sauce or something like that for their children to take the medication.
However, the problem is that sometimes children find it difficult to.... They don't like the taste because sometimes, when the medicines are compounded, they have a taste to them that children don't like. Getting adherence from children to take their medication is difficult at the best of times, so this makes it much more challenging. The advantage of having specific pediatric formulations is that you can make medications for children in forms that are appropriate—like syrups for younger children, or microtablets but with syrup flavours that children like—and children are going to be more compliant with in their therapies.