Maybe I'll start off and then I'll turn it over to Dr. Kaida.
I agree with you that those statistics around one in four women not responding to the first-line treatment certainly underscores the importance of our finding other treatments.
I don't have it handy right now, but I will go back and take a look at what we have funded in this domain to see whether there may be some early studies that are showing some promising treatments and maybe what will go on after that. That's on me to follow up and ensure that I provide you and the committee with that information.
Maybe, Dr. Kaida, the question specifically around the hubs is for you.