Yes, that is a concern. Whether sanctions are hurting the people they're intended to hurt or whether they're hurting innocent people instead, there's no question that the Iranian economy has suffered as a result of the sanctions. Inflation is high. Unemployment is high. Their currency, the rial, has been devalued.
Again I will point out that the Iranian people have not tended to blame the west for their economic conditions right now. They are blaming the government. But secondly, the ideal goal of sanctions is to make life so difficult for the regime that it feels compelled to actually abandon its nuclear weapons ambitions. That may not be realistic, especially given how far they've already come in that. But sanctions might still render the government very vulnerable and unleash domestic Iranian backlash similar to what we saw in 2009, which would revive the internal opposition and topple the regime. It seems that a lot of Iranians would want those things, because they are so disenchanted with their government on so many different levels. So a democratic revolution would optimally, in my opinion, remove the current regime.
There has also been talk about the fact that many Iranians are actually supportive of some sort of nuclear program. Well, other countries have nuclear programs too. This one is scary because of this fourfold threat, because of their involvement in terrorism, and because of their genocidal statements. When you have a peaceful regime, then an ambition to have nuclear capabilities is not nearly as scary for the rest of the world.