Yes.
I have several examples of ones that eventually occurred but that took many years.
Famotidine is an example of where you would have had to research a different use for an already established prescription product. Famotidine has long been used, and has a good safety record, to treat ulcers. But it was perceived by researchers that it could also be used for other upper GI indications--heartburn, reflux esophagitis, and so on. Since the original research as a patented molecule never focused on that aspect of it, it wasn't an approved use for that product. Therefore, our industry had to research and do the clinical trials and so on to show that it could also be used for this other indication, this other use. That cost considerable money. That was one of the products that was switched early in the U.K., and it took another seven years or so in Canada to get that through.
There are other product examples I can give you, such as naproxen sodium--Aleve is a brand name--in the United States. Virtually everybody else in the world switched it, and it took almost 12 years for Canada to do so.