I'll answer quickly.
PMRA and the Japanese regulators seem to be working very well together. We receive advance notice from Japan when they plan to introduce or change MRLs, so it in fact is an example of a country that's working very well.
I think where we could perhaps make some improvement would be to have Japanese regulators more involved in global joint reviews, so that they're more involved earlier on and work towards harmonizing their system with what other regulators in Europe, Australia, Canada, and the U.S. have now moved towards.