Yes, because customs duties are not being collected, for one thing. Secondly, there are losses because sales tax is not being collected. That is a disadvantage.
For my part, all the products I sell are fully taxed and subject to customs duties. That is not true for other companies, however, so there is an imbalance or unfairness in terms of competition.
I am not asking for my business to be subsidized or protected, but simply for things be fair. As citizens, we have responsibilities, and that is expensive. For example, my company pays delivery charges and taxes that go towards maintaining our roads. Amazon, on the other hand, uses our roads to deliver products that are not subject to sales tax.