It's a perfect example.
Large companies have lots of people who can deal with any administrative burden that comes their way. They don't like it, but they have people to do it. Small companies don't. They don't have teams of analysts, lawyers and staffers who can figure out whatever the new regulation is. There is a disproportionate impact on small and medium-sized companies, and on entrepreneurs, actually, who are trying to do business cross-border.
It's tiny differences of regulation that don't mean anything. If the United States and Canada could just say that if it's safe in Canada, it's good enough for the U.S. and vice versa—just a mutual recognition—that would save tens of billions of dollars in the economy. It would help governments, and it would help small businesses the most.