Certainly one element that I would look at is the element of safety in a two-engine design.
The other element is that because of the layout of the aircraft, we are looking at an airplane that has about the same internal fuel fraction as an F-22, in its air defence role when the airplane is clean. If we put extra fuel tanks on the airplane—they are supersonic fuel tanks, and the airplane will fly at Mach 1.8 with three tanks—we're now looking at the same fuel fraction as an F-35.
So I don't think you would see any big differences in the spectrum or the ranges and endurance that we could cover.