Right at the end of World War II the Germans were firing V-2 rockets at London. The Americans came up with a remotely controlled airplane, a bomber, and they filled it full of bombs. They put a remote radio control inside the aircraft. The guys would take off, they would parachute out of the airplane, another airplane would fly along controlling it, and they would guide it into the missile sites. That happened in 1944. Robots have been used to attack missiles for 60 or 70 years.
In terms of defeating UAVs I mentioned earlier that humans will fight both alongside and against robots. Robots will also fight those things as well. There will be counter-UAV robots, counter-UAV UAVs. If they detect it they'll crash into it.
The Israelis are using a system in their northern border for exactly that same reason, but overall you're going to need to detect them and then jam them.