Thank you.
If we are talking specifically about cardiac function tests that are being monitored as a result of a patient, say, receiving chemotherapy, and we want to be certain that the patient's heart isn't being adversely affected, yes, there are alternative tests. Echocardiography would be one. A certain percentage of patients, perhaps up to 15% to 20%, may not be suitable for echocardiography for a number of different reasons. Another possibility would be to use MRI imaging, but with MRI, as Dr. Lyons has described, we run into very significant constraints: it's expensive to do an MRI, they are not particularly widely available, and some patients may not be able to tolerate them because of claustrophobia.
Every time we look at alternatives, we begin to run into some barriers. The system is structured the way it is now because we think that in at least most cases we do the best possible test for the patient. Sometimes we run into barriers because of lack of availability of those tests.