Yes, first patients have to be recruited. It may be very difficult to get them to agree to participate in the research project. It is a new technique and some patients may have concerns. Furthermore, the antibodies may have no effect or the effect may be moderated. There is also the issue of antibody delivery, of how to inject the antibodies. Will intravenous injection have to be done via intrathecal injection directly into the nervous system in order to be effective? We do not presently have the answer to such questions.
On November 2nd, 2010. See this statement in context.