I'm always anxious about this question, because while on the one hand it's the holy grail for all of us, and enormous strides have been made, I'm also always very nervous about setting inappropriately high expectations. People have been saying for many years that the cure is five years away.
So enormous advances have been made, largely because, I would say, of the advances in genetics and because they give insights into mechanisms of cell death. If you have more than one genetic cause, you can look at how they interact and at common pathways. As I mentioned, the other example related to the diabetes drug.
Yes, I would like to say that we're close, but it's complicated, because it's not one cause, not one disease; it's multiple causes. To translate understanding the mechanisms into effective treatments is also a non-trivial challenge.