As you know, RDÉE Canada is the Réseau de développement économique et d'employabilité. It focuses on entrepreneurship, employability and economic development. The AFEC aims to promote economic and trade missions between French-speaking entrepreneurs in these provinces, such as the Rendez-vous d'affaires de la Francophonie, which takes place in Quebec City every two years. I know that the Fédération des chambres de commerce du Québec often sends delegations of French-speaking entrepreneurs who want to do business in Alberta.
The difference between the AFEC and RDÉE Canada is that RDÉE Canada helps entrepreneurs get started in business, while the AFEC has a more economic perspective; it aims for interprovincial exchanges between francophone entrepreneurs.