Patching is number one. It really is.
The second one, depending on what infrastructure you're using, is just not logging in as administrator, not logging in with super privileges, etc. That's a simple thing. It just slows things down.
There is also backing up your data. If you have something critical, make sure you're backing it up, because if ransomware hits, then all you do is restore and you get your data back, and things like that. I'm kind of making it a little simpler than it really is in practice, but these are some basic resiliency things that we'd really look at doing.
We've put out our top 10. Those are more oriented towards larger organizations, but I can translate those into personal actions. It's also knowing what's important to you and making sure you're protecting it, such as keeping backups. For me, I care about family photos and things like that. I honestly don't care about the email I'll never read again that I get on my personal email.