From the spent fuel research into usable fuel, you have to understand the processes and what the risks are with that fuel from a proliferation standpoint, but you also need to be able to understand what the fuel and material components are and how they are going to interact. You want to make sure that you understand the safety cases that those fuels provide to you.
At the end of the day, you also have to understand what waste management processes and procedures you have to put in place to provide a final repository for the spent fuel.