To my mind, no. I have done several studies on this, and there are ways to measure scientific impact at a macro level. The impact of the Quebec scientific community is about 20 per cent above the global average. The global average is 1, while Quebec's is 1.20.
Francophone researchers in the natural sciences are integrated into the global field, whence the title of my old article, "La valeur d'une langue dans un champ scientifique", which is still valid in sociological terms. A scientific field is a community. The Quebec astrophysicists at the Université de Montréal or Université Laval who participate in a conference speak with the other participants, whether they be Chinese, Americans or whatever else, in the lingua franca, which is English. The use of English in the natural sciences is not a problem in any way, in my opinion. We have to let go of this issue in the case of the natural sciences, because it was settled 30 years ago. Instead, we need to focus on the social sciences and humanities.