Really, you need both, and they play different roles.
The initial phases of research cannot be completely directed, because it's not clear ahead of time where the moon shots are going to be. The curiosity-driven research helps us figure out what the moon shots are and what directions are worth having a significant investment.
Most of the curiosity-driven research is happening in academia, but there is also more applied research in academia. The more mission-oriented research is important, because it focuses the efforts in a particular direction; it doesn't explore very widely. Also, you have to realize that it's quite costly to do these things. There are more engineers than researchers, for example. You need both things.
One thing I would like to add here is that I don't think we currently have the right funding style and programs to do moon shot research right now in Canada. Even our funding of industry research tends to be all across the board and not very directed.
As I said, there are good reasons for that. It's not so easy to decide what the right orientations are. That's a place where people like academics, who do the kind of more basic research, can really be helpful and help governments both to identify moon shots and then to evaluate proposals and projects that may come from industry.