It does require us to discuss what a healthy ecosystem looks like. What does the continuum look like? Does it need to be a disease-specific moonshot, or could it be an underlying scientific theme that we understand has relevance to many disciplines and many diseases, and hence my comment on the inflammatory response?
Where I work, the focus for almost all of the diseases is on inflammation and repair. Be it heart disease at the Peter Munk Cardiac Centre, organ transplantation at the Ajmera Transplant Centre or brain disease at the Krembil Brain Neuroscience Institute, the underlying theme is truly inflammation and repair and the sequelae of inflammation. A moonshot that would benefit almost the entire scientific ecosystem as it relates to health and human well-being would be a very fundamental basic science investment. My own personal view would be that it should be inflammation.