One of the recommendations that I and two other expert advisers made to the evidence review team is that using the old randomized trials would really be an error in looking at the new evidence. The reason for that is that the methodology called GRADE, which Dr. Appavoo referred to, automatically characterizes that as the highest quality evidence. It doesn't matter if you include another 90 studies after those randomized trials; it automatically downgrades that.
What we showed in our evidence review is that, if you look at the observational trials, you see that the benefit of reducing mortality was 50%. It is a huge benefit. However, if you only look at the randomized controlled trials, you see that it lowered it to about 20%. This methodology, which was insisted on by the task force, downgraded all of these very large extensive trials that included more modern treatments. That was one of the points that we recognized they had disregarded.