Definitely. There are some different issues at play there.
When you're looking at fatigue, you're looking at sleep debt, time on task, and circadian rhythm. In the case of a long-haul flight, you're looking at a lot of time on task and changes in time zones based on circadian rhythm, and then potentially sleep debt, if your sleep pattern is thrown off according to those changes in time zones and there's not appropriate rest period provided. That being said, for the smaller carriers, I've been there. I've done that. I've flown up in the Arctic. I've flown small planes. It's very taxing when you're doing many different sectors and you're taking off and landing, which are the two most dangerous periods of flight. The majority of accidents and incidents occur during takeoff and landing. As a result of the Colgan Air Flight 3407 investigation by the NTSB in the United States, they actually cited the fact that for landings between midnight and 5 a.m., there is eight times the chance of an accident or an incident, and for takeoffs between midnight and 5 a.m., there is 10 times the chance of an accident or an incident.
It is extremely taxing to have more takeoffs and landings, and it's exposing the individual pilot and the people on board to more risk.