We have other examples of drugs for which we have checklists, patient information and documents you can provide to inform individuals. Actually, I have them sign a contract that they have read it and understand it, and that explicitly tells them what the risks are and what I'm going to do to monitor them, such as bring them back at specified intervals to make sure they're doing okay.
I can think of a way that you could give mefloquine, but I can't think of a situation where you'd really have to. There are a number of alternatives out there, and others coming along—more modern kinds of approaches, vaccines and things of that sort.