I'd really just support what Dr. Sellers has said. This is a complex syndrome and there are multiple players coming into that presentation of the clinical symptomology. However, we do know that there are specific liver enzymes that are involved in drug metabolism that would put a person at higher risk of also having those higher levels accumulating in the brain or being able to reduce the levels in the blood stream more effectively over time. The P-glycoprotein family, which is the transporter that Dr. Sellers is talking about, also has genetic variability and will also facilitate higher levels accumulating in the brain in individuals with particular genetic allelotypes.
There is a genetic screening process that patients who take certain types of toxic drugs—particularly for cancer treatments, for example—need to undergo in order to know that those drugs are going to be metabolized appropriately. That screening process can be undertaken in all individuals for all drug types. It can also inform who potentially may or may not be more susceptible to having a potentially more significant reaction under this accumulated set of circumstances.
I think there is science out there that absolutely supports all of that screening that could occur. It's just something that should be implemented.