I'll speak briefly, and then I think I'll defer to my colleagues in psychiatry, who are perhaps much more familiar with other classes of drug.
I mentioned earlier that it's this entire class of synthetic quinoline drugs, including mefloquine, I suspect chloroquine, certainly atebrin or mepacrine during World War II, and possibly even quinine—which we all have enjoyed at some point in our tonic water—that may have this propensity because of a class effect.
I have written in a few manuscripts that the effects of mefloquine intoxication or encephalopathy do resemble that seen in extreme cases with certain other drugs, including some recreational drugs. One thing I will point out is that the particular combination of symptoms and neurological injury caused by this class of drug, I do feel, is unique. The quinolines were discovered in World War II to cause this absolutely fascinating pattern of microscopic, cell-specific injury to various centres in the brain stem and deep brain, in the limbic system—extraordinary, as described by the authors of that time. To my knowledge, this finding really hasn't been replicated in any other class of drug.
So while some of the effects—I think the psychosis, the memory loss, the changes in behaviour—are certainly shared by a number of other intoxicants, the combination of psychiatric and neurological effects, I do think, is unique to this class.